1. Team Formation:

Please note that any individual expected to view/access any data only available within the N3C Enclave must register with the Enclave and complete all required trainings.

Project Lead: This person will create, manage, and submit appropriate forms, such as DURs, pertaining to the project.

• DUR Submission

• For more Help as Project Lead

  • N3C Office Hours (Tues & Thurs at 10-11 am PT/1-2 pm ET.)

Logic Liaisons extract and transform EHR data to develop reusable code templates and convenient derived datasets, known as Knowledge Objects

• Search “Logic Liaison Template” within the Knowledge Store

• PhenoType Explorer

• #n3c-analytics Slack channel.

• N3C Data and Logic Liaison Services

• N3C Training Portal.

Data Liaison recommend previously validated concept sets or develop new concept sets in consideration of EHR and site data availability and limitations.

• Concept Set Browser and Editor

• N3C Recommended Concept Sets

• OHDSI resources

• Domain Team Meetings

• Enclave-internal ticket system

Subject Matter Experts are reccomended to review and validate concept sets/cohort definitiions o based on their expertise in medical terminology/codes and to ensure appropriate interpretation of results.

• Consider reaching out N3C Domain Teams for quick collaboration among experts familiar witht the N3C interface.

Navigator: For USC-affiliated projects, you can contact the CRI team at cri@usc.edu to request support within the Enclave. A team member may be available to collaborate on your project to assist with Logic and Data Liaison tasks.

More collaboration tools in the N3C

• N3C Community Notes

• Knowledge Store

• Concept Set Browser

2. Develop a Research Project

Define Clinical Questions

• Understand the Data in the Enclave

Submit a DUR

• This creates a unique project workspace for your project.

• Explore your newly created Project Workspace.

Protocol

Link protocols to your project workspace to keep track of your methodology and decisions throughout your project lifecycle. This is very helpful for keeping track of all concept sets, knowledge objects, and datasets used to curate the dataset and conduct the analyses.

• Protocol Pad

Define Cohorts of Interest

Consult subject matter experts and data liaisons to define a cohort using OMOP standardized concepts that fits your research question.

• OHDSI Atlas

• Concept Set Browser to browse recommended and validated concept sets in the

• Logic Liaison QC Template in the Knowledge Store

Select/Edit/Create Concept Sets

Create computable phenotypes using concept sets based on OMOP standardized concepts.

• OHDSI Atlas

• Concept Set Browser and Editor

• Fusion

• Contour

• Code Workbooks

3. Data Curation

Generate Fact Tables (Data Sets)

Fact tables provide essential information for cohort characterization and downstream analyses. Logic Liaison Fact Table Templates enable quick generation of common facts using N3C-vetted concept sets and peer-reviewed code. You can then add project-specific facts to this base table for your analyses.

• Fusion

• Code Workbook

• Code Repository

• Logic Liaison Code Templates in the Knowledge Store

  • Logic Liaison Facts Templates

  • Logic Liaison Quality Control, QC Templates

4. Data Analysis

Develop Analytic Pipeline using Code Workbooks or Code-Free Platforms

• Contour

• Code Workbook

• Code Repository

• Notebook to aid in documentation

5. Manuscript Preparation

Download Data and Results

• Data Download Form

Attestations/Ackowledgements

• Attach all appropriate attestations and acknowledgements to your publication per the Attribution and Publication Policy.

Submit Work to Publication Committee

• Publication Intent Form

• N3C Contributor’s Form